Paracelsus scholars are much indebted to Karl Sudhoff, the late Leipzig professor of the history of medicine. With his comprehensive Versuch einer Kritik der Echtheit der Paracelsischen Schriften in two volumes (1894, 1898), where he describes the Paracelsian prints and manuscripts, he had laid down a solid foundation for Paracelsus studies until today.

In his later years, it was Sudhoff's strong intention to put forward a new edition of Paracelsus's works. In this respect, he resorted to a large extent to Huser's edition, adding only minor writings and letters unkwown to Huser. In trying to simplify the early modern German spelling, Sudhoff introduced a rather idiosyncratic spelling which often leads to ambiguities. Furthermore, he tried to rearrange Huser's order of the writings in order to attain a chronological sequence. However, this attempt appears rather artificial, since for the better part of Paracelsus's works an exact dating is impossible.

Sudhoff implemented in his edtion only sparse textual criticism and no explanatory notes. Notwithstanding all these shortcomings, the Sudhoff Edition remains an important presentation of Paracelsus's natural-philosophic and medical works to this day.